Up to half of prostate cancer (PCa) patients at some stage following diagnosis will undergo androgen deprivation therapy (ADT). However, to avoid initial treatment-related adverse effects on strength and function, exercise therapy should be implemented with initiation of ADT. ConclusionĮxercise either at the onset or after 6 months of ADT preserves/enhances muscle strength and physical function. From 7 to 12 months, DEL increased in all strength measures ( P < 0.001), with no differences between groups at 12 months. There was a significant difference for all strength measures at 6 months favouring IMX ( P < 0.001), with net differences in leg press, seated row and chest press strength of 19.9 kg (95% CI, 12.3–27.5 kg), 5.6 kg (3.8–7.4 kg) and 4.3 kg (2.7–5.8 kg), respectively. Upper and lower body muscle strength and physical function were assessed at baseline, 6 and 12 months. DEL comprised 6 months of usual care followed by 6 months of resistance/aerobic/impact exercise. IMX comprised 6 months of supervised resistance/aerobic/impact exercise initiated at the onset of ADT with a 6-month follow-up. One-hundred-and-four men with PCa (68.3 ± 7.0 years) initiating ADT were randomised to immediate exercise (IMX, n = 54) or delayed exercise (DEL, n = 50) for 12 months. ![]() We examined whether it was more efficacious to commence exercise at the onset of ADT rather than later in treatment to counter declines in strength and physical function. ![]() Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) results in adverse effects, including reduced muscle strength and physical function, potentially compromising daily functioning.
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